ZHANG Yue-Zhou

2019/01/19 14:51  Click:[]

E-mail: iamyzzhang@nwpu.edu.cn, zyuezhouzqx@gmail.com



2009.12-2014.12 Doctorate studies in medicinal chemistry, Faculty of Pharmacy, University of Helsinki, Finland. Under the supervision of Principal Investigator Henri Xhaard, Gustav Boije af Gennäs and Professor Jari Yli-Kauhaluoma. Study organized by the National Doctoral Program in Informational and Structural Biology.

Thesis title: “Investigating phosphate structural replacements through computational and experimental approaches

2008.3-2009.12 Doctorate studies in material engineering, Department of Chemistry, Northwestern Polytechnic University

Project title: “Synthesis and characterization of cellular polyimide material

2005.9-2008.3 Master of Environmental Science (M.Sc.), Department of Chemistry, Northwestern Polytechnic University

Thesis title: “Degradation of Benzene Serial under the Condition of Denitrification”

1999.9-2003.7 Bachelor of Science (B.Sc.), College of Environmental and Chemical Engineering, Xi'an Polytechnic University.


Work experience

2019.01- To date, Tenure-track associate Professor in Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnic University

2016.12-2018.12, Post-doc, working with Assistant professor Hongbo Zhang, Pharmaceutical Sciences Laboratory, Åbo Akademi University, Faculty of Sciences and Engineering, Finland

2016.12-2018.12, supervision of Master students Bram Bogaert, Shahadat Hossain, Wali Inam and Xiaodong Ma; lecturing the pharmaceutical nanotechnology course, particularly the biomedical applicationa of DNA nanotechnology

2015.06-2016.10, Post-doc, worked with Professor Jonathan Baell, Monash Institute of Pharmaceutical Sciences, Monash University, Australia; worked with Professor Robin Gasser, Faculty of Veterinary, University of Melbourne, (Parkville Campus), Australia

2015.01-2015.05 Postdoc fellow, College of Animal Sciences and Technology/College of Veterinary Medicine, Huazhong Agricultural University, China

2009.12-2014.12 Centre for Drug Research and Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. Research assistant at the Computational Drug Discovery group and at the Medicinal Chemistry group (roughly 50-50%). Research grants in 2009.12-2013.12. Employment contracts in 2014.

2008.3-2009.12 Participated into the commercialization of polymethacrylimide foam from laboratory to industry

2003.8-2005.8 Employed by Xi'an Thermal Power Research Institute and served on Thermal Power Plant Chemical Research Center, development of water treatment reagents and estimation of the products of other clients.


Research Areas

- Nanoprecipitation based on microfluidics

- Synthetic medicinal chemistry

- Computer-Aided Drug Design methods and applications: Docking, Pharmacophore modeling, 3D-QSAR, homology modeling

- Data mining for chemoinformatics


Peer-reviewed publications

1. Xiaodong Ma, Ezgi Özliseli, Yuezhou Zhang,* Guoqing Pan, Dongqing Wang,* and Hongbo Zhang.* Fabrication of Redox- Responsive Doxorubicin and Paclitaxel Prodrug Nanoparticles with Microfluidics for Selective Cancer Therapy, Biomaterials Science, 2019, 7(9):634-644 (IF:5.83)

2. Yuezhou Zhang, Henri Xhaard, Leo ghemtio*. Predictive classification models and targets identification for betulin derivatives as Leishmania donovani inhibitors. Journal of Cheminformatics. 2018, 10(1):40 (IF:3.89)

3. Yuezhou Zhang*, Jing Tu, Dongqing Wang, Haitao Zhu, Sajal Kumar Maity, Xiangmeng Qu, Bram Bogaert, Hao Pei, and Hongbo Zhang*. Programmable and Multifunctional DNA-Based Materials for Biomedical Applications. Advanced Materials, 2018, 1703658

4. Yuezhou Zhang, Alexandre Borrel, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Henri Xhaard*. Structural isosteres of phosphate groups in the Protein Data Bank. Journal of Chemical Information and Modeling, 2017,57(3), 499-516

5. Xiuzhen Yang, Tengzhi Zhou, Bozhi Ren, Andrew Hursthouse, Yuezhou Zhang*. Removal of Mn (II) by Sodium Alginate/Graphene Oxide Composite Double-Network Hydrogel Beads from Aqueous Solutions. Scientific Reports, 2018, 8(1):10717

6. Yuezhou Zhang, Mikael Jumppanen, Mirko M. Maksimainen, Samuli Auno, Zulfa Awol, Léo Ghemtio, Hari Venkannagari, Lari Lehtiö, Jari Yli-Kauhaluoma, Henri Xhaard, Gustav Boije af Gennäs*. Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. Bioorganic & Medicinal Chemistry, 2018, 26(8): 1588-1597

7. Xiuzhen Yang, Yuezhou Zhang*, Liping Wang, Lili Cao, Kelin Li and Andrew Hursthouse. 2017, Preparation of a Thermally Modified Diatomite and a Removal Mechanism for 1-Naphthol from Solution. WATER, 2017, 9, (9), 651

8. Zhang, Y. Z, Zhang, G. C, Sun, X. F, He, Z, Rajaratnam, M. Properties and Microstructure Study of Polyimide Foam Plastic. Cellular Polymers, 2010, 29(4):211-226

9. Zhang, Y. Z, Zhang, G. C, He, Z, Sun, X. F, Rajaratnam, M. Visualization Study of Solid Poly (Ester-Amine Salt) Precursor Foaming Process. Cellular Polymers, 2010, 29(1):45-57

10. Yue Qiao, Yuan Ping, Hongbo Zhang, Fengyong Liu, Bo Zhou, Yinhui Yu, Tingting Xie, Wanli Li, Danni Zhong, Yuezhou Zhang, Ke Yao, Hélder A. Santos,* and Min Zhou*. Laser Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Wound Healing for Infected Chronic Nonhealing Wounds. ACS Applied Materials & Interfaces, 2019, 11(4):3809-3822

11. Minghua Yao, Ming Ma*, Hongbo Zhang, Yuezhou Zhang, Gang Wan, Jie Shen, Hangrong Chen*, Rong Wu*. Mesopore-Induced Aggregation of Cobalt Protoporphyrin for Photoacoustic Imaging and Antioxidant Protection of Stem Cell. Advanced Functional Materials, 2018, 1804497

12. Yueqi Zhu#, Hongbo Zhang#, Yiran Zhang#, Huayin Wu, Liming Wei, Gen Zhou, Yuezhou Zhang, Lianfu Deng, Yingsheng Cheng, Minghua Li*, Hélder A*. Santos, Wenguo Cui*. Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. Advanced Materials, 2018, 1805452

13. Dongfei Liu, Salvatore Cito, Yuezhou Zhang, Chang-Fang Wang, Tiina Sikanen and Hélder A. Santos*. A Versatile and Robust Microfluidic Platform towards High Throughput Synthesis of Homogeneous Nanoparticles with Tunable Properties. Advanced Materials, 2015, 27 (14): 2298-2304

14. Sarah Preston, Junjie Luo, Yuezhou Zhang, Abdul Jabbar, Simon Crawford, Jonathan Baell, Andreas Hofmann, Min Hu, Hai-Bing Zhou and Robin B. Gasser*. Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus. Parasites & Vectors, 2016, 9:346

15. Wei-Qiang Lei, James B. Lok, Wang Yuan, Yue-Zhou Zhang, Jonathan D. Stoltzfus, Robin B. Gasser, Si-Yuan He, Huan Zhou, Rui Zhou, Jun-Long Zhao, Min Hu*. Structural and developmental expression of Ss-riok-2, an RIO protein kinase encoding gene of Strongyloides stercoralis, Scientific Reports, 2017, 7(1), 8693

16. Liwei Liu, Jouni Jokela, Bahareh Nowruzi, Matti Wahlsten, Perttu Permi, David P. Fewer, Yuezhou Zhang, Henri Xhaard and Kaarina Sivonen*. Nostosin A and B, trypsin inhibitors isolated from the soil cyanobacterium Nostoc sp. strain FSN. Journal of Natural Products, 2014, 77 (8): 1784-1790

17. Yaoguo Wu*, Lin Hui, Xiang Li, Yuezhou Zhang, And Wencun Zhang. Degradation of aniline in weihe riverbed sediments under denitrification conditions. Journal of Environmental Science and Health Part A (2007) 42, 413-419

18. Lin Hui, Wu Yao-Guo, Li Xiang, Yue-zhou Zhang. Effect of DOM on the mobility of heavy metals in soil. Journal of Liaoning Technical University, 2006, 278-280

19. Yuezhou Zhang, Yaqing Jiao, Sarah Preston, Robin B. Gasser* and Jonathan Baell*. Structure-activity relationship (SAR) of oxadiazol-carboxamide scaffold inhibit motility and development of parasitic stages of Haemonchus contortus. European Journal of Medicinal Chemistry (under preparation)

Book chapter:       

1. Yuezhou Zhang, Dongfei Liu, Hongbo Zhang and Hélder A. Santos. chapter 7, Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery, 2019, 155-177

2. Leo Ghemtio, Yuezhou Zhang and Henri Xhaard. CoMFA/CoMSIA and Pharmacophore Modelling as a Powerful Tool for Efficient Virtual Screening: Application to Anti-Leishmanial Betulin Derivatives. Virtual Screening, chapter 3. ISBN: 978-953-51-0308-0, InTech, DOI: 10.5772/36690

3. Yuezhou Zhang, Dhayakumar Rajan Prakash, Hongbo Zhang. Nucleotide Aptamers as Theranostic Bionanomaterials. Invited Book chapter, Theranostic Bionanomaterials, Elsevier (Accepted)

4. Yuezhou Zhang, Luofeng Yu, Jianhong Zhang and Peng Li. Polymeric Nanoparticulate Delivery Vehicles of Antimicrobials for Biofilm EradicationSpringer (Submitted)



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